Trinnpris angis for ikke-patenterte legemidler, hvor det foreligger generisk konkurranse mellom legemidler som Direktoratet for medisinske produkter har vurdert som likeverdige.
modafinil will lessen the extent or result of pacritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
Medication that have stage therapy linked to Every prescription. This restriction normally necessitates that selected standards be met ahead of approval for the prescription.
Inhibition of platelet aggregation by clopidogrel is totally as a consequence of an active metabolite. Clopidogrel is metabolized to this active metabolite partially by CYP2C19. .
Antonelli et al (1998) tested modafinil’s neuroprotective result regarding glutamate cytotoxicity by measuring GABA launch and GABA uptake in cultured rat cortical neurons. They identified that not like glutamate receptor antagonists, modafinil was unable to thoroughly avoid initial reductions in GABA launch, but modafinil was ready to forestall the additional reduction in GABA release about the subsequent 50 percent hour that was observed while in the cells exposed to glutamate but not modafinil.
It's not at all crystal clear just how modafinil functions to further improve slumber cycles to assist with obstructive sleep apnea, narcolepsy, or change work ailment. It may well contain mimicking chemical compounds within your brain that act like adrenaline or increasing dopamine (A further chemical with your brain) activity.
Stone et al (2002) also claimed the results of strain on modafinil’s stimulation of greater gross movement in live rats, a few of whom had been pretreated with corticosterone or dexamethasone. They pointed out that pressure lessened In general gross motion, an influence attenuated by corticosterone pre-remedy, and tension also lowered the modafinil induced Raise in gross motion.
Not suggested in individuals with angina, cardiac ischemia, and recent record of myocardial infarction, still left ventricular hypertrophy more info or mitral valve prolapse
Modafinil’s system of motion (MOA) stays elusive as identified inside a new editorial on modafinil entitled, “Modafinil: a drug looking for a system” (Saper and Scammell 2004). There has also been investigation into your neuroprotective actions of modafinil, which we suggest to generally be linked to its alerting effects. We selectively evaluation a variety of preclinical and scientific papers applicable to modafinil’s MOA. We conclude with contemplations of MOA, notably mainly because it pertains to modafinil’s effects in addictive Problems.
efavirenz will lower the level or outcome of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
Study all client info, medication guides, and instruction sheets provided to you. Ask your health care provider or pharmacist When you've got any thoughts.
This may not be a complete listing of medicines that can communicate with modafinil. Normally Check out using your healthcare service provider.
danazol will raise the stage or outcome of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unknown.
It's not at all recognised whether or not modafinil passes into breast milk or if it could damage a nursing newborn. Explain to your doctor In case you are breast-feeding a child.